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Image Search Results
Journal: Bioconjugate chemistry
Article Title: A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo
doi: 10.1021/acs.bioconjchem.8b00177
Figure Lengend Snippet: (A) Thiomaltose trimethoprim (TM-TMP): A new trimethoprim prodrug with enhanced water solubility that targets bacteria. (B) Proposed cleavage of TM-TMP in the presence of exogenous thiols.
Article Snippet: Control groups included mice untreated with any drug, and mice treated with
Techniques: Solubility, Bacteria
Journal: Bioconjugate chemistry
Article Title: A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo
doi: 10.1021/acs.bioconjchem.8b00177
Figure Lengend Snippet: Synthesis of thiomaltose-trimethoprim (TM-TMP). (a) DCM, TEA, rt, 55%. (b) DCC, DMAP, TEA, DMF, rt, 29%. (c) CuI, DIPEA, DMSO, rt, 65%.
Article Snippet: Control groups included mice untreated with any drug, and mice treated with
Techniques: